732 research outputs found

    The Excellency of Theology: A Critique of Robert K. Merton\'s \"Puritan Thesis,\" with Reference to the Works of Robert Boyle

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    Robert K. Merton's "Puritan Thesis" asserts a direct correlation between Puritan theological beliefs and participation in natural philosophy (what today would be known as science). This essay corrects the misleading assumptions and conclusions brought about by Merton's argument, by using the writings of Robert Boyle. Boyle, whom Merton designated a "Puritan scientist," wrote extensively on the connection between natural philosophy and theology; and his writings demonstrate that the relationship between the two was far more complex than the simplicity of Merton's thesis suggests

    Resisting the Lure of Certainty, Seeking the Unity of Truth: A Nineteenth-Century Voice with Twenty-first-Century Resonance

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    In her essay, the author seeks to bring the vision of nineteenth-century American philosopher Charles Sanders Peirce to the attention of those involved in the contemporary debate over the relationship between religion and science. Peirce\'s conception of a \"scientific religion \" and the openness of a scientific integrated with the human experience of the divine as a way of overcoming the equating of truth with rigid certainty is of particular relevance today, when the dangers of fundamentalist biblical interpretation are especially evident

    Resisting the Lure of Certainty, Seeking the Unity of Truth: A Nineteenth-Century Voice with Twenty-first-Century Resonance

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    In her essay, the author seeks to bring the vision of nineteenth-century American philosopher Charles Sanders Peirce to the attention of those involved in the contemporary debate over the relationship between religion and science. Peirce\'s conception of a \"scientific religion \" and the openness of a scientific integrated with the human experience of the divine as a way of overcoming the equating of truth with rigid certainty is of particular relevance today, when the dangers of fundamentalist biblical interpretation are especially evident

    Nutritional factors associated with acne vulgaris

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    Acne Vulgaris is a common dermatological condition defined as a chronic inflammatory dermatosis of the pilosebaceous unit that affects more than 17 million Americans.^1 Although it is not considered a dangerous condition, it may drastically impair quality of life and leave a substantial psychological impact.^2 Acne’s multifactorial pathogenesis is typically categorized into four aspects: increased sebum production, altered keratinization, inflammation, and bacterial colonization.^3 Dietary factors contribution to the pathogenesis of acne has remained controversial throughout the literature. However, currently there exists a greater understanding between how diet may influence endocrine factors contributing to acne pathogenesis.^4 Additionally, recent published evidence and public paradigm shifts highlighting the relationship between diet and health have caused a resurgence of this topic, particularly among patients seeking a more gentle, alternate solution to current treatments. Some of the most promising recent correlating evidence supports an association between acne prevalence and dairy consumption, particularly skim milk consumption.^5 It is hypothesized that milk consumption affects the presence of both reproductive, non-reproductive hormones, and growth factors in our body, which may contribute to increased acne prevalence.^6 However, there has been a lack of randomized controlled trials to determine the cause and effects nature of this relationship, as all previous studies are observational.^1 Therefore, this study will conduct a randomized controlled trial to determine the significance between dietary non-fermented dairy consumption and acne prevalence in adolescents. We hypothesize the adaptation of a diet of decreased dairy consumption will decrease the prevalence or severity of acne vulgaris in adolescents between the ages of 13-18. It is our hope that the conclusion of this study will advance our understanding of the dietary correlation between dairy and acne vulgaris in order to provide further insight to guide medical practitioners’ ability to help treat this distressing condition

    Follow-up study of seventy-one pregnant women suspected of having tuberculosis as known to the prenatal clinic of the Boston City Hospital between August 1, 1930 and July 31, 1941

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    This item was digitized by the Internet Archive. Thesis (M.S.)--Boston Universityhttps://archive.org/details/followupstudyofs00pat

    Spotlight on zebrafish:translational impact

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    In recent years, the zebrafish has emerged as an increasingly prominent model in biomedical research. To showcase the translational impact of the model across multiple disease areas, Disease Models & Mechanisms has compiled a Special Issue that includes thought-provoking reviews, original research reporting new and important insights into disease mechanisms, and novel resources that expand the zebrafish toolkit. This Editorial provides a summary of the issue’s contents, highlighting the diversity of zebrafish disease models and their clinical applications

    Long-term non-invasive drug treatments in adult zebrafish that lead to melanoma drug resistance

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    Zebrafish embryos are widely used for drug discovery, however, administering drugs to adult zebrafish is limited by current protocols that can cause stress. Here, we developed a drug formulation and administration method for adult zebrafish by producing food-based drug pellets that are consumed voluntarily. We applied this to zebrafish with BRAF-mutant melanoma, a model that has significantly advanced our understanding of melanoma progression, but not of drug resistance due to the limitations of current treatment methods. Zebrafish with melanomas responded to short-term, precise and daily dosing with drug pellets made with the BRAF(V600E) inhibitor, vemurafenib. On-target drug efficacy was determined by phospho-Erk staining. Continued drug treatment led to the emergence, for the first time in zebrafish, of acquired drug resistance and melanoma relapse, modelling the responses seen in melanoma patients. This method presents a controlled, non-invasive approach that permits long-term drug studies and can be widely applied to adult zebrafish models
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